Dry Cough Dextromethorphan And Noskapin As Antitusif Non-Opioid

Antitusif Non-Opioid

 Dextromethorphan

Dextromethorphan (d-3 metoksin- N metilmorfinan), in contrast with I-isomers, no analgesic effect and is addictive. This substance increases the threshold of stimulation reflex cough-centrally and kekuatanya roughly the same as codeine, unlike codeine these substances rarely cause drowsiness or gastrointestinal disorders. In therapeutic doses of this substance does not inhibit the activity of the cilia of the bronchi and the effects antitusifnya last 5-6 hours.





Low toxicity of these substances at all, but very high doses may cause respiratory depression. Dextromethorphan tersedian in the form of 10 mg tablet and as a syrup with a concentration of 10 mg and 15 mg / 5 ml. Adult dose of 10-30 mg given 3-4 times daily.

Noskapin

Noskapin is a natural alkaloid that along with papaverine derivatives classified benzilisokinolin, obtained from opium (2-methyl-8-methoxy-6, 7 methylenedioxy-1, (6,7 dimethoxy-3-ftalidil), 1,2,3,4- tetrahydroisoquinoline).  
At therapeutic doses, these substances have no effect terhadp SSP, except as an antitussive. Noskapin is pengelepasan histamine patent so that very large doses cause bronkokontriksi and transient hypotension. This substance does not cause habituation or addiction. Doses up to 90 mg does not cause respiratory depression. Noskapin inhibit the contraction of cardiac muscle and smooth muscle, but this effect does not arise in the antitussive doses. Kovulsi cause toxic doses in experimental animals. This drug absorption by the intestine occurred well. Dose 3-4, 15-30 mg daily. A single dose of 60 mg once used for coughs peroksimal. 

Source : apotekers 

Ebay Amplifier Head Laney GH50R Guitar

Laney GH50R brings dual channel tube drive sound british character. Actually, this concept has long promoted by Laney to get quality sound.
On the front panel consists of nine knobs and three switches and one input, very simple and easy to operate. It consists of nine knob reverb, master (out, tone), eq (treble, middle, bass), channel 2 (volume, drives) and channel 1 (drive). Uniquely this amp sound setup two channels available in each chanelnya drive, and equipped with facilities reverb effect digital format.
This amp has a power of 50 watts, in which there are two tubes with characterized the 4x12Ax7 for preamp, and 2xEL34 for output. This makes sound issued became more grim and modern. On the rear panel there is a speaker menu options that have many types (1x8, 1x16,2x16,1x4,2x8 ohms), then no ground link, DI, cabinet emulation, remote (footswich), fx loop (send-return), aux in and power cable. Also equipped with a buffer handles on the left and the right side is certainly easier to carry around.
Presents a selection of sound character drive according to taste, ranging from clean drive to drive a crunchy, or from vintage to modern. Of course, very safe and convenient to use for different types of music.
These amps are classified as hi-gain and produce kerakter sound warm, thick sound range and wide, to drive sound, bursts of distortion of the amp is thicker, gahar and responsive. Footsiwich facility makes it easy for the operation of the channel. Laney GH50R very suitable and recommended all to be installed on the speakers Laney GS412VR charged 4 x 12, four pieces measuring 12 inch speakers. This will ensure sound dynamic, responsive and powerful.

Source : Aslmusik

Tramadol-Specific Drugs Frequently Abused

Lately, more and more we find abuse of certain medicinal drugs (CMD). CMD is a drug that works on the central nervous system in addition to narcotic drugs and psychotropic substances, which in use above the therapeutic dose would cause dependence and typical changes in mental activity and behavior. Examples of drugs containing tramadol, heloperidol, amitriptyline and others. In this article will discuss about the drug tramadol, which in some cases abused its user.

Tramadol

Tramadol is a synthetic analogue of codeine which is an opiate receptor agonist weak. Most of analgetiknya effects caused by inhibition of reuptake of norepinephrine and serotonin. Tramadol is as effective her with morphine or meperidine for mild to moderate pain, but for strong pain or chronic weaker. For his equally effective delivery tramadol with meperidine and less likely to cause respiratory depression in the neonate.
Bioavailability of Tramadol after a single oral dose of 68% and 100% when used IM. Affinity to opiate receptors only 1/6000 of morphine, but the major metabolite demethylation results 2-4 times more patents than the parent drug and serves to cause partial analgetiknya effect. Mixture is a mixture resemik tramadol, which is more effective than each enansionernya. Enansioner (+) binds to the opiate receptors and inhibit serotonin uptake.
Metabolism-Tramadol metabolized hearts and excretion by the kidney, with a half-life of elimination 6 hours and 7.5 hours for the active metabolite. Its analgesic arising after 1 hour of oral administration, and reached its peak after 2-3 hours. Old analgesiknya about 6 hours, and the maximum dose of 400 mg per day.
Side effects- common of nausea, vomiting, dizziness, dry mouth, sedation and headache. Seemed less respiratory depression than morphine ekuianalgetik effects and degrees konstipasinya less than the equivalent dose of codeine. Can cause convulsions or recurrence serangkan convulsions. Respiratory depression as a result of tramadol can be overcome with naloxone, but naloxone may increase the risk of convulsions, whereas analgesic would not be affected by naloxone. Physical abuse and dependence on tramadol have been reported to occur. Tramadol should be kept away from patients with a history of addiction. Because inhibisinya effect on uptake of serotonin, Tramadol should not be used in patients taking monoamine-oxidase inhibitor (MAO).

Source : Apotekers

Important Ways to Use Nose Drops Drug Good And Right

One way to take drugs for the sick nose is by dropped into the nostrils. Drops for the nose is usually used for local effect. Dropper that used to be washed with pure water / clean the heat so that microbes do not enter into the bottle drops containing the drug.

The steps use nose drops to keep in mind is,

1. Prepare the necessary tools, such as a pipette, cotton, wipes, etc.
2. Clean hands
3. Prepare the medication, if necessary warm by rubbing the bottle with both hands, until the same temperature as the body.
4. Open the lid of the bottle drops.
5. If the drug is liquid in the bottle with pipette, then do:
Rinse the dropper with pure water
Pinch rubber dropper, then dip into the liquid drops, then remove the clamps, so that the fluid to enter delam pipette.
Make sure that the dropper dripping liquid that can be used in accordance with the desired size of the drops.
6. Put medicine into one nostril, then go into the other nostril.
7. If any part of drugs coming out of the nostrils, wipe clean with a paper towel.
8. Wash your hands and attach lid and store medications properly.

Source: Apotekers

Review Ibanez Micro RGM55 Electric Guitar Mikro

 

Ibanez Micro RGM55  Electric Guitar Mikro

Small Guitar Powerful

Ibanez makes the latest innovations for a guitar that is unique, which is a kind of micro electric guitar. Of course, the price is much cheaper than Ibanez in general.

Ibanez's physical size is much smaller than Ibanez in general, ie 3/4 of the normal Ibanez. Although small, but spare parts and electronic devices that use standard fixed. Solidbody guitars that have been made in Indonesia using basswood wood with a thickness of 4 cm. Desainya apply multiple grooves cut away to contour the body flat, black pickguard, and a standard tremolo bridge. Enough candy apple red color makes this guitar appear dynamic and elegant. To unify the body and neck using a bolt on the system, the system of using the four screws on the back.

This guitar scale 22.75 "material using maple wood wizard micro triple in the neck. While wearing a rosewood fretboard, incorporating 24 iron steel jumbo frets. The unique inlay this guitar shark teeth motif (Sharktooth) along the fret. Results of playablillty comfortable and good grip, like other types of RG series. Tremolo bridge fix the type used as a prop guitar strings.

For its own electronic RGM55 applying double hamburcker passive pickups that DiMarzio Air Norton pickup (Neck) and DiMarzio The Tone Zone (bridge). This pickup combination provides high sensitivity and responsiveness. Sound clean or distortion is very clear and detailed, suitable for every genre of music. Pickup set with 5 way switch and two knobs are volume and tone.
This guitar course is suitable for beginners as well as professional guitarist.

Source : aslmusik

Metallica Back With Album "Hardwired ... To Self Destruct"

Good news for music lovers metal, band Metallica, the world's biggest metal band will release their 10th studio album titled "Hardwired ... To Self Destruct" on November 18, 2016 via Blackened Recordings.

The album was recorded in their own studio was produced by Fidelman together frontman James Hetfield and drummer Lars Ulirh. To rilisanya will tersedi on CD and in digital download plus. Inside is also a bonus CD riffs that make up the origin of the album along with "The Lord Of Summer" was first introduced in their tour a few years ago.

Source : aslmusik

Ebay Effect Guitar-Zoom G5n Multi-Effect Proscessor

The latest multi-effects processor from Zoom comes to delivering high-quality sound, provide the best experience for guitarists. With so many advantages of this effect is appropriate for the needs of the stage and non stage.

Zoom G5n Multi-effect proscessor

Incredible Sound, Countless Combinations

 

Designed to create an incredible sound, best of Zoom guitar effects. G5n provides plenty of tone that will surely provide the best experience for guitarists.

• The built-in expression pedal for real-time control over volume, tone, or choose the effect

• Input and Output standard full live stage

• Free Zoom Guitar Lab (For Mac / Win)

• 68 high-quality digital effects, including distortion, overdrive, EQ, compression, delay, reverb, flanging, phasing, and chorusing.

Source : AslMusik