Antitusif Non-Opioid
Dextromethorphan
Dextromethorphan (d-3 metoksin- N metilmorfinan), in contrast with I-isomers, no analgesic effect and is addictive. This substance increases the threshold of stimulation reflex cough-centrally and kekuatanya roughly the same as codeine, unlike codeine these substances rarely cause drowsiness or gastrointestinal disorders. In therapeutic doses of this substance does not inhibit the activity of the cilia of the bronchi and the effects antitusifnya last 5-6 hours.Low toxicity of these substances at all, but very high doses may cause respiratory depression. Dextromethorphan tersedian in the form of 10 mg tablet and as a syrup with a concentration of 10 mg and 15 mg / 5 ml. Adult dose of 10-30 mg given 3-4 times daily.
Noskapin
Noskapin is a natural alkaloid that along with papaverine derivatives classified benzilisokinolin, obtained from opium (2-methyl-8-methoxy-6, 7 methylenedioxy-1, (6,7 dimethoxy-3-ftalidil), 1,2,3,4- tetrahydroisoquinoline).
At therapeutic doses, these substances have no effect terhadp SSP, except as an antitussive. Noskapin is pengelepasan histamine patent so that very large doses cause bronkokontriksi and transient hypotension. This substance does not cause habituation or addiction. Doses up to 90 mg does not cause respiratory depression. Noskapin inhibit the contraction of cardiac muscle and smooth muscle, but this effect does not arise in the antitussive doses. Kovulsi cause toxic doses in experimental animals. This drug absorption by the intestine occurred well. Dose 3-4, 15-30 mg daily. A single dose of 60 mg once used for coughs peroksimal.
Source : apotekers
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